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Apraglutide for SR-aGvHD: Results from the phase II STARGAZE trial

By Ella Dixon

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Robert ZeiserRobert Zeiser

Jan 27, 2025

Learning objective: After reading this article, learners will be able to cite a new clinical development in acute graft-versus-host disease.


During the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, the GvHD Hub spoke to Robert Zeiser, Medical Center – University of Freiberg, Freiberg, DE, about results from the phase II STARGAZE trial investigating apraglutide, a GLP-2 analog in steroid-refractory lower-gastrointestinal acute graft-versus-host disease.

Results from the phase II STARGAZE trial

Zeiser discussed the background and rationale of the trial, including endpoint selection. He then discusses the safety and efficacy results, including the stability of response to Days 56 and 91 of the trial, and future clinical trials.